诊断-增生性肠炎.ppt

1、第十三节：增生性肠炎（Ileitis),一、概念 猪增生性肠炎又称增生性肠病，是小肠和结肠黏膜增生形成肠腺瘤样结构，又称为肠腺瘤病或回肠炎。,二、病原及发病机理（一）病原：病原为专性细胞内寄生菌，又称劳氏细胞内菌（lawsons）。,Ileitis-Warthin-Starry silver stain 回肠炎：沃斯银染Lawsonia intracellularis in apical cytoplasma of crypt cells.Lawsonia intracellularis（细胞内罗松氏菌）隐窝细胞胞浆上方的病原,Ileitis-Warthin Starry stain回肠炎：沃

2、斯银染curved intracellular Lawsonia organisms.弯曲的细胞内罗松氏菌,（二）发病机理：肠道感染后8-10天即可出现病变，21天时病变达到高峰，使肠道黏膜陷窝上皮增生形成腺瘤样结构，病猪表现为消瘦和不规律腹泻。,三、病理变化（一）急性出血性回肠炎。,Normal正常,villi destroyed损伤的绒毛,Ileitis 血粪，黑粪猪下痢,Ileitis-dark colonic and cecal content回肠炎黑色的结肠盲肠内容物,Ileitis回肠炎出血,Ileitis with regional,segmental distribution回

3、肠炎界线明显的病变,（二）回肠坏死性肠炎。,纤维坏死性肠炎，隐窝扩张，分支，增生,Crypt proliferation and absence of goblet cells隐窝增生和杯状细胞缺失,（三）肠腺腺瘤形成。,Branching proliferating crypts分支和增生的隐窝,Dilated and branching crypts,very few goblet cells扩张和分支的隐窝，少量杯状细胞,Proliferative Enteritis增生性肠炎Fibrinonecrotic colitis纤维坏死性结肠炎Crypt hyperplasia隐窝肥大Dila

4、ted crypts隐窝扩张Absence of goblet cells杯状细胞缺失,Ileitis-Hyperplasia of muscular layer of intestine回肠炎小肠肌层肥厚,Proliferative enteropathy-crypt hyperplasia增生性肠病隐窝肥大,Hyperplastic,dilated crypts肥大，扩张的隐窝,Hyperplastic,dilated crypts肥大扩张的隐窝,Colon-dilated crypts结肠扩张的隐窝,Hyperplasia,necrosis,and scarring of colonic crypts结肠隐窝的增生，坏死和瘢痕形成,四、鉴别诊断（一）细菌性肠炎（二）劣质饲料引起的肠炎（三）梭菌性肠炎,