信号通路专用名词缩写.docx

信号通路专用名词缩写.docx

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4E-BPeIF-4Ebindingprotein

AblAblesonproteintyrosinekinase

ACTRAhistoneacetyltransferase

AKTCellularhomologofthev-aktoncogene,anS/Tproteinkinase

Apaf-1Apoptoticproteaseactivatingfactor-1

APCAdenomatouspolyposiscoli

APPb-amyloidprecursorprotein

APPsAcutephaseproteins

ASKApoptosissignal-regulatingkinase

ATF1Activatingtranscriptionfactor1,TREB36

ATF2Activatingtranscriptionfactor2,CRE-BP1,CREB2

ATMAtaxia-telangiectasiamutatedproteinkinase

ATRATM+Rad3-relatedproteinkinase

BclBcellleukemiaoncogene

BMPBonemorphogeneticprotein

BRCABreastcancergrowth-suppressorprotein

CADCaspase-activateddeoxyribonuclease

CaM-KCalcium/calmodulin–dependentkinase

CasCrk–associatedsubstrate,p130CAS

CaspaseCysteineproteaseswithaspartatespecificity

CBPCREBbindingprotein

Cdc2Celldivisioncycleprotein2,CDK1

Cdc25cCelldivisioncycleprotein25,M-phaseinducerphosphatase3

Cdc34Celldivisioncycleprotein34,anE2ubiquitinconjugatingenzyme

Cdc42Celldivisioncycleprotein42,aGprotein

CDKCyclin-dependentkinase

ChkCheckpointkinase

CHOPC/EBPhomologousprotein

CipCdk-interactinprotein

CISCytokineinducibleSH2-containingprotein

CK1Caseinkinase1

c-MybCellularhomologoftheavianmyeloblastosisvirusoncogene

c-RafRafproto-oncogeneS/Tproteinkinase

CREBcAMPresponseelement-bindingprotein,CREB1

DAGDiacylglycerol

DaxxFasdeathdomain-associatedprotein

DNA-PKDNA-activatedproteinkinase

DP-1MemberoftheE2Ftranscriptionfactorfamily

DPC4Deletedinpancreaticcancerlocus4,SMAD4

DR3Deathreceptor3

DshDishevelled

dsRNADouble-strandedRNA

E2FTranscriptionfactorfamilyincludingE2F-andDP-likesubunits

eEFEukaryoticelongationfactor

eIFEukaryoticinitiationfactor

ELK1Etsdomainprotein

eNOSEndothelialnitricoxidesyntase,NOS-III

EREndoplasmicreticulum

EREstrogenreceptor

ERKExtracellularsignal-regulatedkinase,MAPK

FADDFas-associatedproteinwithdeathdomain

FAKFocaladhesionkinase

FKHRForkheadinrhabdomyosarcoma

FLIPsFLICE（Caspase8）inhibitoryprotein

FRAPFKBP12-rapamycin-associatedprotein

FRS2FGFreceptorstimulated,lipid-anchoredGrb2bindingprotein

GADD45GrowtharrestandDNAdamageprotein45

GAPGTPaseactivatingproteins

GASIFNg-activatingsequence

GCKGerminalcenterkinase

GCN2Generalcontrolofaminoacidbiosynthesisprotein2,aS/Tkinase

GCN5Generalcontrolofaminoacidbiosynthesisprotein5,ahistoneacetyltransferase

GEFGuaninenucleotideexchangefactor

GPCRG-proteincoupledreceptor

GRB2Growthfactorreceptor-boundprotein2

GRIPGlucocorticoidreceptorinteractingprotein,ahistoneacetyltransferase

GRKG-proteincoupledreceptorkinase

GSK-3bGlycogensynthasekinase-3b

HDACHistonedeacetylase

HMGHighmobilitygroup

HPKHematopoieticprogenitorkinase

HRIHemin-regulatedinhibitor,aS/Tkinase

HSP27Heatshockprotein27

IAPInhibitorofapoptosis

ICADInhibitorofcaspase-activateddeoxyribonuclease

IkBInhibitorofNF-kB

IKKIkBkinase

INK4InhibitorofCDK4

IRSInsulinreceptorsubstrate

ISREInterferon-stimulatingresponseelement

JakJanus-familytyrosinekinase

JNKJunN-terminalkinase

KSRKinasesuppressorofRas

LC8Dyneinlightchain,cytoplasmic

M3/6Adual-specificityphosphatase

MAPKMitogen-activatedproteinkinase

MAPKAP-2MAPkinase-activatedproteinkinase2

MDM2Murinedoubleminute-2,ap53-associatedoncogene

MEF2Myocyteenhancerfactor2

MEKMAPK/ERKkinase,MAPKK

MEKKMEKkinase

MKPMAPkinasephosphatase

MLKMixedlineagekinase

MNKMAPkinase-interactingkinase

MSK-1Mitogenandstress-activatedkinase1

mTORMammaliantargetofrapamycin

MyoDMyogenicdeterminationfactor

Myt1Adual-specificityproteinkinase

NcoRNuclearreceptorcorepressor

NFAT4NuclearfactorofactivatedTcells4

NF-kBNuclearfactorkappaB

NIKNF-kBInducedkinase

NLKNEMO-likekinase

p19Arfp19alternativereadingframeprotein,atumorsuppressor

p300Ahistoneacetyltransferase

p53TumoursuppressorproteinthatprotectsfromDNAdamage

PABPPoly（A）tail-bindingprotein4

PARPPoly（ADP-ribose）polymerase,ADPRT

PaxPaxilin

PCAFp300/CBP-associatedfactor,ahistoneacetyltransferase

pCIPp300/CBPinteractingprotein,ahistoneacetyltransferase

PDK3-phosphoinositide-dependentproteinkinase

PEKPancreaticeukaryoticinitiationfactor2a-subunitkinase

PERKTypeItransmembraneER-residentproteinkinase

PI3KPhosphoinositide-3kinase

PIASProteininhibitorsofactivatedSTATs

PIP2Phosphatidylinositol3,4-bisphosphate

PIP3Phosphatidylinositol3,4,5-trisphosphate

PKAProteinkinaseA

PKCProteinkinaseC

PKRdsRNA-dependentserine/threonineproteinkinase

PLCbPhospholipaseCb

PLCgPhospholipaseCg

Plk1Polo-likekinase1

PLP2APhospholipase2A

PP1Phosphoproteinphosphatase1

PP2APhosphoproteinphosphatase2A

PP2BPhosphoproteinphosphatase2B

PPARgPeroxisomeproliferator-activatedreceptorg

PRProgesteronereceptor

PRAKp38regulatedactivatedkinase

PTENPhosphataseandtensinhomologdeletedonchromosometen

PYK2Proline-richtyrosinekinase-2

RAIDDRIP-associatedICH/CED-3-homologousproteinwithadeathdomain

RbRetinoblastomaprotein,atumorsuppressor

RGSRegulatorofGproteinsignaling

RIPReceptor-interactingprotein

RSKRibosomalS6kinase

RTKReceptortyrosinekinase

RXRRetinoidXreceptor

S6SmallsubunitribosomalproteinS6

S6KS6kinase

SAPKStress-activatedproteinkinase

SCFSkp-Cdc53-F-boxubiquitinligasecomplex

ShcSH2-containingcollagen-relatedproteins

SHP1SH2-containingphosphatase1

SHP2SH2-containingphosphatase2

Sin3Atranscriptionalcorepressor

SKP2S-phasekinaseassociatedprotein2

SmadContractionofSmaandMad（Mothersagainstdecapentaplegic）

SMRTSilencingmediatorofretinoicacidandthyroidhormonereceptor

SOCSSuppressorsofcytokinesignalling

SosSonofsevenlessguaninenucleotideexchangefactor

SOXSRY-relatedHMGboxprotein

SRC1Steroidreceptorcoactivator1,ahistoneacetyl-transferase

SRFSerumresponsefactor

STATSignaltransducerandactivatoroftranscription

TAFsTBP-associatedfactors

TAKTGFb-activatedkinase

TalTalin

tBidTruncatedBid

TBPTATA-bindingprotein

TCFT-cellfactor,aWntsignalingtranscriptionfactor

TFTranscriptionfactor

TGFTransforminggrowthfactor

THTyrosinehydroxylase

TIMPTissueinhibitorofmetalloproteinases

Tip60HIV-1-Tatinteractiveprotein,ahistoneacetyl-transferase

TNFTumornecrosisfactor

TRThyroidhormonereceptor

TRADDTNFreceptor-1-associateddeathdomainprotein

TRAF2TNFreceptor-associatedfactor2

VDACVoltage-dependentanionchannel

Wee1Auniversalmitoticinhibitorkinase

WntContractionof‘Wingless’and‘Int’