商务智能聚六亚甲基双胍盐酸盐.docx

商务智能聚六亚甲基双胍盐酸盐.docx

《商务智能聚六亚甲基双胍盐酸盐.docx》由会员分享，可在线阅读，更多相关《商务智能聚六亚甲基双胍盐酸盐.docx（33页珍藏版）》请在冰点文库上搜索。

商务智能聚六亚甲基双胍盐酸盐

Title:

Activeingredientcombinationsofpolyhexamethylenebiguanidinehydrochlorideanddistearyldimethylammoniumchlorideandpreparationscomprisingsaidactiveingredientcombinations

DocumentTypeandNumber:

UnitedStatesPatentApplication20060018847

KindCode:

A1

Abstract:

Theinventionisanactiveingredientcombinationcomprisingpolyhexamethylenebiguanidinehydrochlorideanddistearyldimethylammoniumchlorideandacosmeticordermatologicalformulationcomprisingpolyhexamethylenebiguanidinehydrochlorideanddistearyldimethylammoniumchloride.Theinventionalsoincludesmethodsoffightingorpreventingdermatologicalharmcomprisingapplyingtotheskinacosmeticordermatologicalformulationcomprisingpolyhexamethylenebiguanidinehydrochlorideanddistearyldimethylammoniumchloride.Theinventionalsoincludesmethodsofpreventingdecayoforganicsubstancesinaformulation,comprisingaddingtosaidformulationpolyhexamethylenebiguanidinehydrochlorideanddistearyidimethylammoniumchloride.

AdsbyGoogle

Glycidylmethacrylate

Methacrylicacidoracrylicacidwithavarietyofdifferentalcohol

AntibioticResistance

ProtectionAgainstCatheter-RelatedBloodstreamInfections.ReadMore..

8MGuanidineSolution

Highpurity8MGuanidine-HClforproteinsolubilization&refolding.

LotrylResins

ArkemamanufacturesLotrylResinsEBAandEMAcopolymers

www.arkema-

StaphAureusCounts

ReduceStaphAureusCounts,WipersImproveIPAContactTimes.SeeHow!

www.F

Inventors:

Kroepke,Rainer（Schenefeld,DE）

Zelle,Dagmar（Bliedersdorf,DE）

Filbry,Alexander（Hamburg,DE）

Hamer,Gunhild（Hamburg,DE）

     PlaqueIt!

ApplicationNumber:

11/090693

PublicationDate:

01/26/2006

FilingDate:

03/25/2005

ViewPatentImages:

ImagesareavailableinPDFformwhenloggedin.ToviewPDFs,Login  or CreateAccount（Free!

）

ExportCitation:

Clickforautomaticbibliographygeneration

Assignee:

BeiersdorfAG

PrimaryClass:

424/78.270

OtherClasses:

424/59,514/635,514/643

InternationalClasses:

A61K7/42;A61K31/155;A61K31/14

Attorney,AgentorFirm:

ALSTON&BIRDLLP;BANKOFAMERICAPLAZA（101SOUTHTRYONSTREET,SUITE4000,CHARLOTTE,NC,28280-4000,US）

Claims:

Thatwhichisclaimed:

1.Anactiveagentcombination,comprisingpolyhexamethylenebiguanidinehydrochlorideanddistearyldimethylammoniumchloride.

2.Acosmeticordermatologicalformulation,comprisingpolyhexamethylenebiguanidinehydrochlorideanddistearyldimethylammoniumchloride.

3.Thecosmeticordermatologicalformulationasclaimedinclaim2,furthercomprisingatleastoneantioxidant.

4.Thecosmeticordermatologicalformulationasclaimedinclaim2,furthercomprisingatleastoneUVfiltersubstance.

5.Thecosmeticordermatologicalformulationasclaimedinclaim2,whereinsaidformulationisintheformofanemulsion.

6.Thecosmeticordermatologicalformulationasclaimedinclaim2,whereinsaidformulationisintheformofanoil-in-wateremulsion.

7.Thecosmeticordermatologicalformulationasclaimedinclaim2,whereinsaidformulationisintheformofawater-in-oilemulsion.

8.Thecosmeticordermatologicalformulationasclaimedinclaim2,comprisingfrom0.01to20%byweightintotalofthecombinationofpolyhexamethylenebiguanidinehydrochlorideanddistearyldimethylammoniumchloride,basedonthetotalweightoftheformulation.

9.Thecosmeticordermatologicalformulationasclaimedinclaim8,comprisingfrom0.02to5%byweightintotalofthecombinationofpolyhexamethylenebiguanidinehydrochlorideanddistearyidimethylammoniumchloride,basedonthetotalweightoftheformulation.

10.Thecosmeticordermatologicalformulationasclaimedinclaim9,comprisingfrom0.05to3%byweightintotalofthecombinationofpolyhexamethylenebiguanidinehydrochlorideanddistearyidimethylammoniumchloride,basedonthetotalweightoftheformulation.

11.Amethodofpreventingthegrowthofbacteria,mycobionts,andviruses,comprisingapplyinganactiveagentcombinationcomprisingpolyhexamethylenebiguanidinehydrochlorideanddistearyldimethylammoniumchloride.

12.Amethodoffightingorpreventingdermatologicalharm,comprisingapplyingtotheskinacosmeticordermatologicalformulationcomprisingpolyhexamethylenebiguanidinehydrochlorideanddistearyldimethylammoniumchloride.

13.Themethodasclaimedinclaim12,whereinsaidformulationcomprisesfrom0.01to20%byweightintotalofthecombinationofpolyhexamethylenebiguanidinehydrochlorideanddistearyldimethylammoniumchloride,basedonthetotalweightoftheformulation.

14.Themethodasclaimedinclaim12,whereinsaidformulationcomprisesfrom0.02to5%byweightintotalofthecombinationofpolyhexamethylenebiguanidinehydrochlorideanddistearyldimethylammoniumchloride,basedonthetotalweightoftheformulation.

15.Themethodasclaimedinclaim12,whereinsaidformulationcomprisesfrom0.05to3%byweightintotalofthecombinationofpolyhexamethylenebiguanidinehydrochlorideanddistearyldimethylammoniumchloride,basedonthetotalweightoftheformulation.

16.Themethodasclaimedinclaim12,forpreventingorimprovingneurodermatitis.

17.Themethodasclaimedinclaim12,forpreventingthegrowthoforkillingStaphylococcusaureus.

18.Amethodofpreventingdecayoforganicsubstancesinaformulation,comprisingaddingtosaidformulationpolyhexamethylenebiguanidinehydrochlorideanddistearyldimethylammoniumchloride.

19.Themethodasclaimedinclaim18,whereinsaidformulationcomprisesfrom0.01to20%byweightintotalofthecombinationofpolyhexamethylenebiguanidinehydrochlorideanddistearyldimethylammoniumchloride,basedonthetotalweightoftheformulation.

20.Themethodasclaimedinclaim18,whereinsaidformulationcomprisesfrom0.02to5%byweightintotalofthecombinationofpolyhexamethylenebiguanidinehydrochlorideanddistearyldimethylammoniumchloride,basedonthetotalweightoftheformulation.

21.Themethodasclaimedinclaim18,whereinsaidformulationcomprisesfrom0.05to3%byweightintotalofthecombinationofpolyhexamethylenebiguanidinehydrochlorideanddistearyldimethylammoniumchloride,basedonthetotalweightoftheformulation.

Description:

CROSS-REFERENCETORELATEDAPPLICATIONS

ThisisacontinuationapplicationofPCT/EP02/10817,filedSep.26,2002,whichclaimsthebenefitofDE10147186.6,filedSep.25,2001.

FIELDOFTHEINVENTION

Thepresentinventionconcernsactiveingredientcombinationscomprisingpolyhexamethylenebiguanidinehydrochlorideanddistearyidimethylammoniumaswellastheuseofactiveingredientcombinationsasagentsagainstbacteria,mycotaandviruses,inparticularforpreservingcosmeticanddermatologicalemulsions.Inparticularembodiments,thepresentinventionconcernspreparations,preferablycosmeticanddermatologicalpreparationscontainingsuchsubstances.

BACKGROUNDOFTHEINVENTION

Healthywarm-bloodedorganisms,inparticularhealthyhumanskin,arecolonizedbyawidevarietyofnonpathogenicmicroorganisms.Theseso-calledmicrofloraoftheskinarenotonlyharmless,butalsorepresentanimportantformofprotectionasadefenseagainstopportunisticorpathogenicmicrobes.

Bacteriabelongtotheprokaryoticsingle-celledorganisms.Theycanbecrudelydistinguishedaccordingtotheirshape（ball,cylinder,bentcylinder）aswellasthestructureoftheircellwall（gram-positive,gram-negative）.Thephysiologyoftheorganismsalsoallowsforfinerdistinctions.Therethusexistaerobic,anaerobicandfacultativelyanaerobicbacteria.Manyindividualsareofmedicalsignificanceowingtotheircharacteristicaspathogenicmicrobes,whileothersarecompletelyharmless.

Substanceseffectiveagainstbacteriahavebeenknownforsometimenow.Nevertheless,manyoftheseantibacterialagentsarenotsuitableforallmedical,letalonecosmetic,applications,asthemetabolicfunctionsofthewarm-bloodedorganism,inotherwordsthediseasedpatient,arealsoaffectedbytheapplicationinonewayoranother.

Gram-negativemicrobesaretypicallyEscherichiacoli,PseudomonasspeciesaswellasenterobacteriasuchasCitrobacterfreundii.

Evengram-positivemicrobesplayaroleincosmeticsanddermatology.Thus,forexample,bacterialsecondaryinfectionsarealsoofetiologicalsignificancebesidesotherinfluences.OneofthemostimportantmicroorganismsassociatedwithuncleanskinisStaphylococcusaureus.ThisisresponsibleforthesymptomsImpetigofollicularis,furunculosis,abscesses,sepsis,pemphigusneonatorum,toxicshocksyndrome,foodpoisoningetc.Inadditiontothis,examinationshaverevealedthatahighpercentage（over90%ofthoseaffected）ofneurodermatitispatientsexhibitedan,inpart,extremelyhighcontentofStaphylococcusaureusontheskin.

Incontrasttobacteria,fungi（alsoreferredtomycotaormycobionts）belongtotheeukaryotes.Incontrasttotheso-calledprokaryotes（procytes）,eukaryotesarelivingorganismswhosecells（eucytes）haveacellnucleusseparatedfromtheremainingcytoplasmbyanuclearenvelopeandnuclearmembrane.Thecellnucleuscontainsthegeneticinformationstoredinchromosomes.

Typicalrepresentativesofthemycobiontsincludeyeasts（Protoascomycetes）,moulds（Plectomycetes）,mildews（Pyrenomycetes）,falsemildews（Phycomycetes）andmushroomsortoadstools（Basidiomycetes）.

FungidonotbelongtothePlantKingdom,butlikeplantshaveacellwallaswellasvacuolesfilledwithcellsapandplasmastreamingcl