雅思阅读考试巩固试题附答案Word文档格式.docx

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雅思阅读考试巩固试题附答案Word文档格式.docx

  ChangesinAir

  A

  Afederalbanonozone-depletingchlorofluorocarbons(CFCs),toconformwiththeCleanAirAct,is,ironically,affecting22.9millionpeopleintheU.S.whosufferfromasthma,Geneticinhaledalbuterol,whichisthemostcommonlyprescribedshort-actingasthmamedicationandrequiresCFCstopropelitintothelungs,willnolongerbelegallysoldafterDecember31,2008.Physiciansandpatientsarequestioningthewisdomoftheban,whichwillhaveaninsignificanteffectonozonebutameasurableimpactonwallets:

thereformulatedbrand-namealternativescanbethreetimesasexpensive,raisingthecosttoabout$40perinhaler.Theissueisevenmoredisconcertingconsideringthatasthmadisproportionatelyaffectsthepoorandthataccordingtorecentsurveys,anestimated20percentofasthmapatientsareuninsured.

  B

  Thedecisiontomakethechangewaspolitical,notmedicalorscientific,sayspharmacistLeslieHendelesoftheUniversityofFlorida,whoco-authoreda2007paperintheNewEnglandJournalofMedicineexplainingthewithdrawalandtransition.In1987CongresssignedontotheMontrealProtocolonSubstancesThatDepletetheOzoneLayer,aninternationaltreatyrequiringthephasingoutofallnonessentialusesofCFCs.Atthattime,medicalinhalerswereconsideredanessentialusebecausenoviablealternativepropellantexisted.In1989pharmaceuticalcompaniesbandedtogetherandeventually,in1996,reformulatedalbuterolwithhydrofluoroalkane.

  C

  Thetransitionbeganquietly,butasmorepatientsseetheirprescriptionschangeandcostsgoup,manyquestionwhythisbailmustbeginbeforegenericsbecomeavailable.AtleastonememberoftheFDAadvisorycommittee,NicholasJ.GrossoftheStritch-LoyolaSchoolofMedicine,haspubliclyregrettedthedecision,recantinghissupportandrequestingthatthebanbepushedbackuntil2010,whenthefirstpatentexpires.

  D

  GrossnotesthatthedecisionhadnothingtodowiththeenvironmentAlbuterolinhalerscontributedlessthan0.1percentoftheCFCsreleasedwhenthetreatywassigned.Lt&

#39;

sasymbolicissueGrossremarks.SomeskepticsinsteadpointtothebillionsofdollarstobegainedbythethreecompaniesholdingthepatentsontheavailableHFA-albuterolinhalers,namelyGlaxo-SmithKline,Schering-PloughandTeva.AlthoughtheFDAadvisorycommitteerecognizedthattheexpenseswouldgoup,Hendelessays,italsobelievedthatthecompanieswouldhelpdefraytheaddedcostsforindividuals,Firms,forinstance,hadcommittedtodonatingamillionHFAinhalerstoclinicsaroundthecountry.AccordingtoHendeles,GlaxoSmithKlinedidnotfollowthrough,althoughSchering-PloughandTevadid.GlaxoSmithKlinedidnotrespondtorequestsforcomment.

  E

  Theissuenow,Hendelessays,isthatpharmaceutical-gradeCFCsareinshortsupply,andthepublicfacestheriskofashortageofalbuterolinhalersiftheFDAdoesnotcontinuepromotingtheproductionofHFAinhalers.HepositsthatevencostsofgenericswouldgoupasCFCsbecomescarcer.Grossdisagrees,sayingthattheinhalershortageandtheclosureofCFCmanufacturingplantsarearesultoftheban.

  F

  TheHFAinhalersalsohaveencounteredresistancebecausesomeasthmaticsinsistthattheydonotworkaswellastheCFCvariety.But,Hendelessays,thedifferencesareinthemechanicsandmaintenance&

mdash;

unlikeCFCinhalers,theHFAversionsmustbeprimedmorediligentlyandrinsedtoaccommodatethestickierHFAformulation.TheyalsorunoutsuddenlywithoutthewarningwithaCFCinhaler,thatthedeviceisrunninglow.Pharmacistsmaynottellpeopleofthesethings,andthedoctorsdon&

tknow,Hendelessays.

  G

  Themainpublichealthissueinthisdecisionmaybethesideeffectsoftheeconomics,notthedrugchemistry.Multiplestudieshaveshownthatraisingcostsleadstopooreradherencetotreatment.Onestudydiscoveredthatpatientstook30percentlessamtiasthmamedicationwhentheirco-paydoubled.Intheeaseofachronicdiseasesuchasasthma,itisparticularlydifficulttogetpeopletofollowregulartreatmentplans.Generallyspeaking,foranyreasonyoudon&

rsquo;

ttakemedication,costmakesitmorelikely&

rdquo;

thatyoudonot,commentsMichaelChernew,ahealthpolicyexpertatHarvardMedicalSchool.

  H

  Suchchoicestoforgomedicationcouldaffectmorethanjustthepatientsthemselves.Forexample,Hendelespointsout,inapregnantmotherwithuntreatedasthma,lessoxygenisdeliveredtothefetus,whichcanleadtocongenitalproblemsandprematurebirth.Andconsideringthatthediseasedisproportionatelystrikesthepoor,whatseemedtobeagood,responsibleenvironmentaldecisionmightintheendexactanunexpectedhumantoll.

  Question14-18

  Usetheinformationinthepassagetomatchthepeople(listedA-C)withopinionsordeedsbelow.WritetheappropriatelettersA-Cinboxes14-18onyouranswersheet.

  NByoumayuseanylettermorethanonce

  ANicholasJ.Gross

  BMichaelChernew

  CLeslieHendeles

  14.Putforwardthattheincreaseinthepriceofdrugswouldcontributetothepatients&

negativedecisiononthetreatment.

  15.Spokeoutasecretthatthedruggiststrytoholdback.

  16.Pointedoutthattheprotocolitselfisnotconcerningtheenvironment.

  17.DemonstratedthatthestopofprovidingalternativesforCFCswouldworsenratherthanhelpwiththesituation.

  18.Inpublicrepentedofhispreviousbackingupoftheprohibitionproposal.

  Question19-22

  DothefollowingstatementsagreewiththeinformationgiveninReadingPassage?

  Inboxes19-22onyouranswersheet,write

  TRUEifthestatementistrue

  FALSEifthestatementisfalse

  NOTGIVENiftheinformationisnotgiveninthepassage

  19.Ittookalmostadecadebeforethereplacementdrugfortheasthmatherapywasultimatelydevelopedbythejointeffortofseveraldrugcompanies.

  20.OneoftheFDAcommitteemembershadadecisiveimpactontheimplementofthebanonchlorofluorocarbons.

  21.Asamatteroffact,theemittedchlorofluorocarbonsinasthmatreatmenttookupquiteaninsignificantamountatthetimewhenthepactwasreached.

  22.TheHFAandCFCinhalershavesomethingdifferentregardingthetherapeuticeffect.

  Question23-27

  CompletethefollowingsummaryoftheparagraphsofReadingPassage,usingNoMorethanThreewordsfromtheReadingPassageforeachanswer.Writeyouranswersinboxes23-27onyouranswersheet.

  Americanpeoplewithasthmawouldbeimpactedby...23...aboutchlorofluorocarbonswhichwouldconsumetheozonelayer.Theusuallyused...24...wouldbeconsideredillegalbecauseitneedsthepropelmentof...25....The...26...wouldcostthepatientsconsiderablymoremoney.ImpoverishedpeoplearefarmorelikelytoSufferfromasthmaandwhatmakesitevenworseisthatsomeofthemarein...27...condition.

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