雅思阅读模拟试题.doc

雅思阅读模拟试题.doc

《雅思阅读模拟试题.doc》由会员分享，可在线阅读，更多相关《雅思阅读模拟试题.doc（4页珍藏版）》请在冰点文库上搜索。

　　2011雅思阅读模拟试题精选

　　Whydidapromisingheartdrugfail?

　　Doomeddrughighlightscomplicationsofmeddlingwithcholesterol.

　　1.Thefailureofahigh-profilecholesteroldrughasthrownaspotlightonthecomplicatedmachinerythatregulatescholesterollevels.Butmanyresearchersremainconfidentthatdrugstoboostlevelsof'good'cholesterolarestilloneofthemostpromisingmeanstocombatspirallingheartdisease.

　　2.DrugcompanyPfizerannouncedon2Decemberthatitwascancellingallclinicaltrialsoftorcetrapib，adrugdesignedtoraiseheart-protectivehigh-densitylipoproteins（HDLs）。

Inatrialof15000patients，asafetyboardfoundthatmorepeoplediedorsufferedcardiovascularproblemsaftertakingthedrugplusacholesterol-loweringstatinthanthoseinacontrolgroupwhotookthestatinalone.

　　3.Thenewscameasakickintheteethtomanycardiologistsbecauseearliertestsinanimalsandpeoplesuggesteditwouldlowerratesofcardiovasculardisease."Therehavebeennoredflagstomyknowledge，"saysJohnChapman，aspecialistinlipoproteinsandatherosclerosisattheNationalInstituteforHealthandMedicalResearch（INSERM）inPariswhohasalsostudiedtorcetrapib."Thiscancellationcameasacompleteshock."

　　4.TorcetrapibisoneofthemostadvancedofanewbreedofdrugsdesignedtoraiselevelsofHDLs，whichferrycholesteroloutofartery-cloggingplaquestotheliverforremovalfromthebody.Specifically，torcetrapibblocksaproteincalledcholesterolestertransferprotein（CETP），whichnormallytransfersthecholesterolfromhigh-densitylipoproteinstolowdensity，plaque-promotingones.Statins，incontrast，mainlyworkbyloweringthe'bad'low-densitylipoproteins.

　　Underpressure

　　5.Researchersarenowtryingtoworkoutwhyandhowthedrugbackfired，somethingthatwillnotbecomeclearuntiltheclinicaldetailsarereleasedbyPfizer.Onehintliesinevidencefromearliertrialsthatitslightlyraisesbloodpressureinsomepatients.Itwasthoughtthatthismildproblemwouldbeoffsetbytheheartbenefitsofthedrug.Butitispossiblethatitactuallyprovedfatalinsomepatientswhoalreadysufferedhighbloodpressure.Ifbloodpressureistheexplanation，itwouldactuallybegoodnewsfordrugdevelopersbecauseitsuggeststhattheproblemsarespecifictothiscompound.OtherprototypedrugsthatarebeingdevelopedtoblockCETPworkinaslightlydifferentwayandmightnotsufferthesamedownfall.

　　6.ButitisalsopossiblethatthewholeideaofblockingCETPisflawed，saysMotiKashyap，whodirectsatherosclerosisresearchattheVAMedicalCenterinLongBeach，California.WhenHDLsexcretecholesterolintheliver，theyactuallyrelyonLDLsforpartofthisprocess.SoinhibitingCETP，whichpreventsthetransferofcholesterolfromHDLtoLDL，mightactuallycauseanabnormalandirreversibleaccumulationofcholesterolinthebody."You'reblockingaphysiologicmechanismtoeliminatecholesterolandeffectivelyconstipatingthepathway，"saysKashyap.

　　Goingup

　　7.Mostresearchersremainconfidentthatelevatinghighdensitylipoproteinslevelsbyonemeansoranotherisoneofthebestroutesforhelpingheartdiseasepatients.ButHDLsarecomplexandnotentirelyunderstood.Oneapproveddrug，calledniacin，isknowntobothraiseHDLandreducecardiovascularriskbutalsocausesanunpleasantsensationofheatandtingling.Researchersareexploringwhethertheycanbypassthissideeffectandwhetherniacincanlowerdiseaseriskmorethanstatinsalone.Scientistsarealsoworkingonseveralothermeanstobumpuphigh-densitylipoproteinsby，forexample，introducingsyntheticHDLs."Theonlythingweknowisdeadinthewateristorcetrapib，notthewholeideaofraisingHDL，"saysMichaelMiller，directorofpreventivecardiologyattheUniversityofMarylandMedicalCenter，Baltimore.

　　（613wordsnature）

　Thispassagehas7paragraphs1-7.

　　Choosethecorrectheadingforeachparagraphfromthelistofheadingsbelow.

　　Writethecorrectnumberi-ixinboxes1-7onyouranswersheet.

　　ListofHeadings

　　i.Howdoestorcetrapibwork?

　　ii.Contradictoryresultpriortothecurrenttrial

　　iii.Onefailuremaypossiblybringaboutfuturesuccess

　　iv.Thefailuredoesn‘tleadtototallossofconfidence

　　v.Itistherightroutetofollow

　　vi.Whyit‘sstopped

　　vii.Theymaycombineandtheoreticallyproduceidealresult

　　viii.What‘swrongwiththedrug

　　ix.Itmightbewrongatthefirstplace

　　Exampleanswer

　　Paragraph1iv

　　1.Paragraph2

　　2.Paragraph3

　　3.Paragraph4

　　4.Paragraph5

　　5.Paragraph6

　　6.Paragraph7

　　Questions7-13

　　Matchtorcetrapib，HDLs，statinandCETPwiththeirfunctions（Questions8-13）……

　　WritethecorrectletterA，B，CorDinboxes8-13onyouranswersheet.

　　NBYoumayuseanylettermorethanonce.

　　7.Ithasbeenadministeredtoover10，000subjectsinaclinicaltrial.

　　8.Itcouldhelpridhumanbodyofcholesterol.

　　9.Researchersareyettofindmoreaboutit.

　　10.Itwasusedtoreducethelevelofcholesterol.

　　11.AccordingtoKashyap，itmightleadtounwantedresultifit‘sblocked.

　　12.Itproducedcontradictoryresultsindifferenttrials.

　　Listofchoices

　　A.Torcetrapic

　　B.HDLS

　　C.Statin

　　D.CETP

　SuggestedAnswersandExplanations

　　1.vi

　　2.ii

　　3.vii本段介绍了torcetrapib和statin的治病原理，但是同时短语“incontrast”与之前第二段后半段的内容呼应，暗示了这两种药在理论上能相辅相成，是理想的搭配。

第一个选项无法涵盖整段意义，故选择i是错误的。

　　4.iii本段分析了可能导致torcetrapibl临床试验失败的原因，后半段指出如果以上推测正确，那么未来的药物可借鉴这个试验，设法避免torcetrapib的缺陷，研制出有效的药物。

viii选项无法涵盖后半段的意思。

　　5.ix见首句。

　　6.v

　　7.A见第二段。

题目中administer一词意为“用药”，subject一词为“实验对象”之意。

　　8.B见第四段“…toraiselevelsofHDLs，whichferrycholesteroloutofartery-cloggingplaquestotheliverforremovalfromthebody.”即HDLs的作用最终是将choleserol清除出人体：

“…forremovalfromthebody”。

　　9.B见第四段“ButHDLsarecomplexandnotentirelyunderstood.”

　　10.C见第二段“…plusacholesterol-loweringstatin”，即statin是可以降低cholesterol的。

　　11.D见第六段“SoinhibitingCETP，…mightactuallycauseanabnormalandirreversibleaccumulationofcholesterolinthebody.

　　12.A见第三段。

　　13.C见第四段“Statins，incontrast，mainlyworkbyloweringthe'bad'low-densitylipoproteins.”