FDA批准的抗肿瘤药物1949Word文件下载.docx

FDA批准的抗肿瘤药物1949Word文件下载.docx

《FDA批准的抗肿瘤药物1949Word文件下载.docx》由会员分享，可在线阅读，更多相关《FDA批准的抗肿瘤药物1949Word文件下载.docx（64页珍藏版）》请在冰点文库上搜索。

Methotrexate

LederleLaboratories

Dec071953

busulfanoral

Myleran

ChronicMyelogenousLeukemia-palliativetherapy

Jun261954

Mar181957

thiotepa

Thioplex

Mar091959

Aug101959

nandrolonephenpropionate

Durabolin-50

Organon

Oct301959

cyclophosphamide

Cytoxan,Neosar

Bristol-MyersSquibb

Nov161959

CytoxanInjection

DROMOSTANOLONEPROPIONATE

DROMOSTANOLONE

EliLilly

Oct261961

fluorouracil,5-FU

Adrucil

prolongsurvivalincombinationwithleucovorin

ICNPuertoRico

Apr251962

UracilMustard

UracilMustardCapsules

RobertsLabs

Sep131962

vincristine

Oncovin

Jul101963

melphalan,L-PAM

Alkeran

Jan171964

dactinomycin,actinomycinD

Cosmegen

Feb041964

MASTERONEINJECTION

SYNTEX

Oct081964

quinacrine

Atabrine

AbbottLabs

Dec071964

Cosmegan

Dec101964

vinblastine

Velban

Nov051965

thioguanine,6-TG

Thioguanine

Jan181966

pipobroman

Vercyte

Jul011966

hydroxyurea

Hydrea

Dec071967

testolactone

Teslac

Jun031969

cytarabine

Cytosar-U

Pharmacia&

UpjohnCompany

Jun171969

procarbazine

Matulane

SigmaTauPharms

Jul221969

plicamycin,mithramycin

Mithracin

PfizerLabs

May051970

May271970

mitotane

Lysodren

Jul081970

floxuridine（intraarterial）

FUDR

Roche

Dec181970

megestrolacetate

Megace

Aug181971

Nov011971

calusterone

Methosarb

Feb201973

bleomycin

Blenoxane

Jul311973

mitomycinC

Mutamycin

May281974

doxorubicin

Adriamycin,Rubex

Aug071974

dacarbazine

DTIC-Dome

Bayer

May271975

lomustine,CCNU

CeeBU

Aug041976

carmustine

BCNU,BiCNU

Mar071977

tamoxifen

Nolvadex

AstraZenecaPharmaceuticals

Dec301977

cisplatin

Platinol

Metastatictesticular-inestablishedcombinationtherapywithotherapprovedchemotherapeuticagentsinpatientswithmetastatictesticulartumorswhochavealreadyreceivedappropriatesurgicaland/orradiotherapeuticprocedures.AnestablishedcombinationtherapyconsistsofPlatinol,BlenoxaneandVelbam.

Dec191978

Metastaticovariantumors-inestablishedcombinationtherapywithotherapprovedchemotherapeuticagents:

Ovarian-inestablishedcombinationtherapywithotherapprovedchemotherapeuticagentsinpatientswithmetastaticovariantumorswhohavealreadyreceivedappropriatesurgicaland/orradiotherapeuticprocedures.AnestablishedcombinationconsistsofPlatinolandAdriamycin.Platinol,asasingleagent,isindicatedassecondarytherapyinpatientswithmetastaticovariantumorsrefractorytostandardchemotherapywhohavenotpreviouslyreceivedPlatinoltherapy.

estramustine

Emcyt

palliationofprostatecancer

Dec241981

streptozocin

Zanosar

Antineoplasticagent.

May071982

etoposide,VP-16

Vepesid

Refractorytesticulartumors-incombinationtherapywithotherapprovedchemotherapeuticagentsinpatientswithrefractorytesticulartumorswhohavealreadyreceivedappropriatesurgical,chemotherapeuticandradiotherapeutictherapy.

Nov101983

Asasingleagenttodelaybreastcancerrecurrencefollowingtotalmastectomyandaxillarydissectioninpostmenopausalwomenwithbreastcancer（T1-3,N1,M0）

Dec031986

VePesid

Incombinationwithotherapprovedchemotherapeuticagentsasfirstlinetreatmentinpatientswithsmallcelllungcancer.

Dec301986

Leucovorin

Jan301987

daunorubicin,daunomycin

Cerubidine

IncombinationwithapprovedanticancerdrugsforinductionofremissioninadultALL.

WyethAyerst

Mar111987

Apr291987

CytoxanTablet

AdriamycinPFSInjectionintravenousinjection

Antibiotic,antitumoragent.

Dec231987

mitoxantrone

Novantrone

Forusewithotherapproveddrugsintheinitialtherapyforacutenonlymphocyticleukemia（ANLL）inadults.

osteosarcoma

Apr071988

Aug311988

Oct311988

ifosfamide

IFEX

Thirdlinechemotherapyofgermcelltesticularcancerwhenusedincombinationwithcertainotherapprovedantineoplasticagents.

Dec301988

mesna

Mesnex

Preventionofifosfamide-inducedhemorrhagiccystitis

AstaMedica

carboplatin

Paraplatin

Palliativetreatmentofpatientswithovariancarcinomarecurrentafterpriorchemotherapy,includingpatientswhohavebeenpreviouslytreatedwithcisplatin.

Mar031989

Foruseinpremenopausalwomenwithmetastaticbreastcancerasanalternativetooophorectomyorovarianirradiation

Mar161989

pegademase

Adagen（PegademaseBovine）

Enzymereplacementtherapyforpatientswithseverecombinedimmunodeficiencyasaresultofadenosinedeaminasedeficiency.

Enzon

Mar211990

levamisole

Ergamisol

Adjuvanttreatmentincombinationwith5-fluorouracilaftersurgicalresectioninpatientswithDukes'

StageCcoloncancer.

JanssenResearchFoundation

Jun181990

Foruseinwomenwithaxillarynode-negativebreastcanceradjuvanttherapy.

Jun211990

Aug151990

idarubicin

Idamycin

Foruseincombinationwithotherapprovedantileukemicdrugsforthetreatmentofacutemyeloidleukemia（AML）inadults.

AdriaLaboratories

Sep271990

altretamine

Hexalen

Singleagentpalliativetreatmentofpatientswithpersistentorrecurrentovariancancerfollowingfirst-linetherapywithacisplatinand/oralkylatingagentbasedcombination.

USBioscience

Dec261990

Filgrastim

Neupogen

Amgen,Inc

Feb201991

fludarabine

Fludara

PalliativetreatmentofpatientswithB-celllymphocyticleukemia（CLL）whohavenotrespondedorhaveprogressedduringtreatmentwithatleastonestandardalkylatingagentcontainingregimen.

BerlexLaboratoriesInc.

Apr181991

Initialchemotherapyofadvancedovariancarcinomaincombinationwithotherapprovedchemotherapeuticagents.

Jul051991

pentostatin

Nipent

Singleagenttreatmentforadultpatientswithalphainterferonrefractoryhairycellleukemia.

Parke-DavisPharmaceuticalCo.

Oct111991

Incombinationwithfluorouraciltoprolongsurvivalinthepalliativetreatmentofpatientswithadvancedcolorectalcancer.

Dec121991

Aldesleukin

Proleukin

ChironCorp

May051992

teniposide,VM-26

Vumon

Incombinationwithotherapprovedanticanceragentsforinductiontherapyinpatientswithrefractorychildhoodacutelymphoblasticleukemia（all）.

Jul141992

Systemicadministrationforpalliativetreatmentofpatientswithmultiplemyelomaforwhomoraltherapyisnotappropriate.

Nov181992

paclitaxel

Taxol

Treatmentofpatientswithmetastaticcarcinomaoftheovaryafterfailureoffirst-lineorsubsequentchemotherapy.

Dec291992