精品年产300吨庆大霉素发酵车间的工艺设计毕业论文任务书.docx
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精品年产300吨庆大霉素发酵车间的工艺设计毕业论文任务书
目录
设计任务书
1.设计依据及设计原则·······················································1
1.1设计依据································································1
1.1.1主要文件···························································1
1.1.2主要技术资料·······················································1
1.2设计原则································································3
2.产品方案··································································3
2.1产品规格·······························································3
2.2产品主要物性····························································4
2.3分析方法·······························································4
3.生产方法及工艺流程·······················································4
3.1生产方法································································4
3.2工艺过程································································5
3.2.1工艺流程框图·······················································5
3.2.2工艺流程说明·······················································5
3.3设备框图································································6
3.4生产特点·······························································7
3.5工艺介质的腐蚀性·······················································7
3.6带控制点的工艺流程图····················································7
4.原料及中间产品的技术规格················································8
5．物料衡算··································································9
5.1主要物性参数····························································9
5.2物料衡算································································9
5.2.1公称体积与台数的计算···············································9
5.2.2物料衡算··························································10
5.3物料衡算框图···························································11
6.能量衡算·································································11
7.设备计算及选型原则······················································13
7.1设备衡算·······························································13
7.1.1大罐······························································13
7.1.2中罐······························································14
7.1.3小罐······························································15
7.2设备选型的原则·························································16
8.车间布置·································································16
8.1车间的生产性质·························································16
8.2车间布置说明··························································16
8.2.1生产工艺·························································16
8.2.2设备安装检修······················································16
8.2.3安全技术··························································16
8.3设备安装要求···························································17
8.3.1情况介绍··························································17
8.3.2安装方案··························································17
9.生产制度和车间定员······················································17
9.1生产制度·······························································17
9.2岗位操作时间表和班组安排···············································17
9.3车间定员表·····························································17
10.设备·····································································18
10.1车间设备概况··························································18
10.1.1种子制备设备····················································18
10.1.2种子罐··························································18
10.1.3发酵罐··························································18
10.2车间设备材料的选择原则················································18
10.3关键设备······························································18
11.仪表及控制······························································18
11.1生产过程特点概述······················································18
11.2工艺参数控制要求······················································18
11.3仪表及自控方案························································19
12.电气·····································································19
12.1车间用电情况··························································19
12.2车间用电要求··························································19
13.给排水··································································19
13.1生产用水情况概述······················································19
13.2生产用水要求··························································19
13.3排水系统的划分························································20
14．暖通·····································································20
14.1生产特点及工作环境的说明··············································20
14.2车间暖通要求··························································20
15.消防·····································································20
15.1发酵车间生产特性概述··················································20
15.2发酵车间消防要求······················································20
16.车间维修································································21
17.环境保护································································21
17.1生产过程中三废排放情况················································21
17.2处理方案······························································21
18.工业卫生及安全防护····················································21
18.1生产特点······························································21
18.2工业卫生及安全防护要求················································21
19.节能·····································································21
19.1能耗分析······························································21
19.2节能措施······························································22
20.设计总结································································22
21.参考文献································································22
任务书
课题：
年产300吨庆大霉素发酵车间的工艺设计
一、课题的目的、意义：
1、通过该课程的学习将化工原理、工程制图、药剂学、制药工程等方面的知识有机地联系在一起并用于实际生产设计中，巩固已学的知识。
2、掌握制药工程设计的任务、步骤和方法，完成制药工程中某单元反应或局部车间的初步设计，为以后的毕业设计打下基础。
3、通过模拟工程设计，了解工程设计的一般过程，学会收集数据、查找手册、工艺计算、罐体设计以及车间设计平面图设计，掌握工程设计中物料衡算、能量衡算，设备计算等计算。
二、制药工程课程设计的内容和要求：
课程设计是制药工程课程中综合性和实践性较强的环节，要求学生能利用本课程与前修课程的基础知识，了解工程设计的基本内容，掌握药厂设计的基本步骤和方法，培养学生综合应用知识解决实际问题的能力，培养学生工程实际理念和严谨的科学作风。
本课程包含课程涉及的基础知识，包括工艺设计说明书、工艺路线的选择、物料衡算或能量衡算或主体设备设计计算及选型等，并绘制带控制点工艺流程图或车间平面布置图或主体设备图。
三、设计说明书及图纸要求：
1、设计工作量要求：
应按设计工作安排圆满完成设计任务，完成一张A1设计图纸，编写课程设计说明书；
2、说明书及图纸质量要求：
设计说明书应包括设计任务书、工艺路线的选择、物料衡算或能量衡算或主体设备计算及选型等，参考文献等相关内容，做到条理清楚，论据充分，计算详实。
图纸要求布局合理，线条清晰，粗实分明，图例图标符合设计规范。
年产300吨庆大霉素发酵车间的工艺设计
1.设计依据及设计原则
1.1设计依据
1.1.1主要文件:
设计任务书
1.1.2主要技术资料
1、设计技术指标
本设计主要以相关的发酵技术工艺、培养基配方、工艺流程等过程为基础和参考，来进行对年产300吨庆大霉素工程发酵车间工艺的设计。
主要设计的参考参数如下：
（1）、发酵系统（产量300吨年）
发酵单位：
1400（uml）成品单位：
600（umg）
发酵周期：
136（）空压机出口压力：
0.25~0.3（Mpa）
进罐空气温度：
40~45℃进总过滤器的相对湿度：
60%
空气洁净度：
100级
（3）、连续灭菌系统
培养基灭菌处理量：
20（m3-1）]d=4其中d=0.108取n=27，分为3组。
B：
内排管
取DN6576×3管，间距1.5d，每组二进二出高约5.65m，组数
，取4组。
所以，
。
因为，
，所以是适合的。
C：
管径
大罐设备选型与计算汇总：
（1）选型：
D=3500mm，H=8700mm，V0=76.51m3，人孔取600mm，视镜Dg=125mm，支座采用裙座。
（2）筒体壁厚16mm，封头壁厚18mm。
（3）冷却水进水总管直径：
取DN100φ108×3的外盘管盘27圈分为3组，DN65φ76×3的内排管16根分4组，换热面积为49.57m²，壁距0.15m。
外盘总管为DN100φ108×3，内排总管为DN65φ76×2.5，汇总管为DN250φ273×3.5。
7.1.2中罐
。
中罐设备选型与计算汇总：
（1）选型：
D=2000mm，H=4500mm，V0=141.40m3，人孔取500mm，视镜Dg=125mm，支座采用裙座。
（2）筒体壁厚4mm，封头壁厚6mm。
（3）DN100φ1083的外盘管盘两圈，DN65φ76×2.5的内排管，冷却水进水总管直径：
取DN50φ57×2.5外盘总管DN65φ76×2.5，内排总管DN25φ32×2.5。
汇总管取DN80φ89×3，管间距等同上。
7.1.3小罐
：
小罐设备选型与计算汇总：
（1）选型：
D=1000mm，H=2400mm，V0=22.84m3，手孔取Dg250mm，视镜Dg=800mm，支座采用耳式支座。
（2）筒体壁厚10mm，封头壁厚12mm。
7.2设备选型的原则
1、保证工艺过程实施的安全可靠（包括设备材质对产品质量的安全可靠，设备材质强度的耐温、耐压、耐腐蚀的安全可靠，生产过程清洗）；
2、经济上合理，技术上先进，结构合理，工艺符合要求；
3、投资省，耗材少，加工方便，采购容易；
4、运行费用低，水电气消耗少；
5、操作清洗方便，耐用易修，备品配件供应可靠，减轻人工劳动强度，实施机械化和自动化方便；
6、结构紧凑，尽量采用经济可靠、实践证明性能优良的设备；
7、考虑生产波动与年设备平衡，留有裕量；
8、考虑设备故障及检修的备用。
8.车间布置
8.1车间的生产性质
本车间为硫酸庆大霉素发酵车间，由三部分组成，分别为培养基配置连消系统、空气系统与发酵系统。
生产车间一般含生产、辅助、生活三部分。
生产部分包括配料、种子组、发酵、无菌室、摇瓶培养室等；辅助部分包括变电配电室、化验室、仪表控制室等；生活部分包括车间办公室、更衣室、休息室、浴室等。
8.2车间布置说明
8.2.1生产工艺
（1）、为了保证工艺生产要求，在设计中尽量保证布置得流水性，将储槽及重型设备安排在底层。
发酵罐操作面布置在三楼,穿过二楼至一楼设置底座裙座；中罐、补全料罐、补稀料罐操作面在三楼，穿过三楼楼板，底座在二楼楼板为裙座；小罐在三楼用耳式支架固定；氨水储罐、消沫油罐、氢氧化钠储罐安装在三楼。
为了便于操作，第三层楼面为统一操作面，并在三楼安排控制室，分析室。
二楼安排种子组，分析室，仪器室；一楼安排配电间、仓库、机修间，办公室及更衣室卫生间。
（2）、发酵罐中心间距6.6m，已留有管道布置及情况检修操作余地，设备与墙距大于1m。
（3）、设备基本呈对称分布。
8.2.2设备安装检修
由于发酵对环境要求控制较高，需要经常对设备进行维修与更换，因此布置时必须考虑到设备的安装、维修、拆卸的方便可行性。
一般厂房大门要比设备宽0.2m，而对发酵罐大设备，可采用拆框架结构的外墙予以更新。
多层厂房内，每层楼面上设一个吊装门，层顶设计吊装支架。
发酵罐上方顶栅上，设吊装工字钢架，用于电动机及蛇管的拆装。
各种子罐、发酵罐都设有人孔或手孔以便检修，设视镜以便监测。
各设备间要留有空位，离墙、地面均保持一定间距，以便于检修。
车间应设有电梯。
8.2.3安全技术
1、创造良好的采光条件，设备布置尽量做到人员背光操作，高大设备避免靠窗布置，以免影响采光。
2、对于发酵工段大量产热的车间，可采取机械通风措施，设计时也充分考虑空间大小。
3、对于易被腐蚀的设备，加强设备的防护。
4、仪表控制室四周装有玻璃隔窗，以减少工人在车间高噪音下工作。
5、为利于采光和通风，车间布局上发酵罐位于北侧，中小罐位于南侧。
6、防爆车间应加强通风换气，保证易燃易爆物质在空气中的浓度不大于爆炸极限浓度。
7、整个厂房应加强防雷措施。
8.3设备安装要求
8.3.1情况介绍
施工时，先由设计说明书造基，后将大罐安装入室后再造楼层；外墙预留开口，待中罐进入后再砌封；小罐等安装到位之后才依次安装。
框架结构完工后再建底楼楼墙面。
车面内设有工字钢架，吊装口，异轨，电梯以方便安装与检修。
8.3.2安装方案
超大件现场组装设备说明：
在本设计工段中大罐（发酵罐）须现场组装，首先在厂房两侧墙未砌时，将大罐吊装完毕后封墙，通过人孔用典葫芦吊装内排管，最后安装搅拌与电机。
中罐也必须现场吊装，步骤基本与大罐相同，小罐先将罐体吊入装好后，再装上搅拌装置与电机。
在打框架结构时，底楼墙最后建，以便于设备的管道安装。
9.生产制度和车间定员
9.1生产制度
发酵生产的不间断性使工厂必须24小时工作，由于一个工人每天工作8h，一周休息2天，因而采用四班三倒制，以8天为一个周期，每天每班1h吃饭休息。
发酵车间工人分为4组，两天轮换一个班次，具体如下：
早班7：
30-15：
30中班15：
30-23：
30晚班23：
30-次日7：
30
9.2岗位操作时间表和班组安排
班次
1
2
3
4
5
6
7
8
早
A
A
B
B
C
C
D
D
中
B
B
C
C
D
D
A
A
晚
C
C
D
D
A
A
B
B
休息
D
D
A
A
B
B
C
C
注：
小罐每天9:
00接种，中罐每天15:
30接种，大罐每天5:
30接种，大罐每天10:
30放罐
9.3车间定员表
车间定员表
序号
岗位或职号
每班人数
组长
组员
1
种子组
1
3
2
种子罐组
1
3
3
发酵罐组
1
3
4
化验组
1
3
5
修配组
1
3
6
消毒员
2
7
技术员
2
8
副总工程师
1
9
总工程师
1
小计
26
总计
104
附：
总计（人数）=小计（人数）×4个班组
10.设备
10.1车间设备概况
10.1.1种子制备设备
菌种组的日常工作是制备种子液供种子罐使用，另负责菌种保藏的防菌种退化，超时还承担生产菌种的分离纯化和筛选工作。
根据种子组的职能，设置了无菌室，摇瓶间以及菌种储藏室，在无菌室中主要设备是超净工作台，其空气净化达到100级要求，完全能满足无菌要求，环境要求10000级。
在摇瓶间的主要设备是摇瓶机，一般情况下选择单轴旋转式摇瓶机，也可选择变速摇瓶机或往复式摇瓶机。
10.1.2种子罐
种子罐的功能是将摇瓶种子扩大培养成一定量的种子液供发酵罐培养发酵。
由工艺要求，采用二级种子罐，接种量均为15%，接种方式有火焰接种及压力差接种两种方法。
采用火焰接种时，要求周围空气较洁净，
升级会员 