Recent years have seen the development of a number of automated and semiautomated systems to suppor.docx

Recent years have seen the development of a number of automated and semiautomated systems to suppor.docx

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Recentyearshaveseenthedevelopmentofanumberofautomatedandsemiautomatedsystemstosuppor

Questionnaireandinterviewsurveyof16contractualrelationships.►Earlyproviderparticipationisassociatedwithlowerfrequenciesofchange.►Clientsmoreoftenthinkthatchangeisduetoincreasedtechnicalunderstanding.►Projectlifecycleofformal/informalinformationaffectsagilepracticestransfer.

508

Advancesinon-linemonitoringandcontrolofmammaliancellcultures:

SupportingthePATinitiative  ReviewArticle

BiotechnologyAdvances,Volume27,Issue6,November-December2009,Pages726-732

A.P.Teixeira,R.Oliveira,P.M.Alves,M.J.T.Carrondo

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509

TheAttenuationofVeryLowFrequencyBrainOscillationsinTransitionsfromaRestStatetoActiveAttention  OriginalResearchArticle

JournalofPsychophysiology,Volume23,Issue4,2010,Pages191-198

SuzannahK.Helps,SamanthaJ.Broyd,ChristopherJ.James,AnkeKarl,EdmundJ.S.Sonuga-Barke

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510

Technologicaladvancementsinsynchronouscollaboration:

Theeffectof3Dvirtualworldsandtangibleuserinterfacesonarchitecturaldesign  OriginalResearchArticle

AutomationinConstruction,Volume20,Issue3,May2011,Pages270-278

NingGu,MiJeongKim,MaryLouMaher

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AbstractAbstract|Figures/TablesFigures/Tables|ReferencesReferences

Abstract

Thispaperpresentsandevaluatestwocurrentadvancementsofcollaborativetechnologiesforarchitecturaldesign.Thepaperfocusesontechnologiesthatsupportsynchronousdesigncollaboration,inparticular,3Dvirtualworldsforsupportingremotedesigncollaboration,andtangibleuserinterfaces（TUIs）forenhancingco-locateddesigncollaboration.Bothtechnologiesenabledesignerstocollaboratebyinteractingwith3Dmodelsasthedesignrepresentations.Thepaperanalyzestheeffectofthesetechnologiesondesigncollaborationandcognitionthroughacomprehensiveinterpretationoftheresultsfromtwoindependentstudies.Thesetwostudies,usingprotocolanalysisandeachfocusingonadifferentmodeofdesigncollaboration,providethefoundationforcharacterizingthedesigners'cognition,communicationandinteractionwhenusingthenewtechnologies.The3Dvirtualworldsstudyinvestigatesremotedesigncollaborationina3Dvirtualworldinordertounderstandthechangesofdesignbehaviorwhendesignersarephysicallyremotebutvirtuallyco-locatedasavatarswithintheirdesignrepresentationintheformofa3Dmodel.TheTUIstudymeasurestheeffectofatabletopsystemthatintegratesTUIstogetherwithaugmentedreality（AR）ondesigners'cognitiveactivitiesanddesignprocessinco-locateddesigncollaboration.Finally,theanalysisandcomparisonoftheresultsconvergeinasetofrecommendationsforthefuturedevelopmentofcollaborativedesigntechnologies.

ArticleOutline

1.Introduction

2.Collaborativedesigntechnologiesandprotocolanalysis

2.1.Collaborativedesignstudiesandtechnologies

2.2.Protocolanalysis—amethodforstudyingcognitionindesigncollaboration

3.Supportingremotedesigncollaborationin3dvirtualworlds

3.1.Experimentsandcodingschemedesign

3.2.Protocolanalysisresultsanddiscussion

4.Enhancingco-locateddesigncollaborationwithtangibleuserinterfaces

4.1.Experimentsandcodingschemedesign

4.2.Protocolanalysisresultsanddiscussion

5.Conclusion

References

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Researchhighlights

►Thisresearchanalyzestheeffectoftwocollaborativetechnologies,3Dvirtualworldsandtangibleuserinterfaces,ondesigncollaborationandcognitionusingprotocolanalysis.►Twostudiesfocusingremoteandco-locateddesigncollaborationprovidethefoundationforcharacterizingthedesigners’cognition,communicationandinteractionwhenusingthenewtechnologies.►Thisresearchmakesasetofrecommendationsforthefuturedevelopmentofcollaborativedesigntechnologiesbasedontheanalysisandcomparisonoftheresults.

511

SystematicanalysisandpredictionoflongevitygenesinCaenorhabditiselegans  OriginalResearchArticle

MechanismsofAgeingandDevelopment,Volume131,Issues11-12,November-December2010,Pages700-709

Yan-HuiLi,Meng-QiuDong,ZhengGuo

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AbstractAbstract|Figures/TablesFigures/Tables|ReferencesReferences

Abstract

Animportanttaskofagingresearchistofindgenesthatregulatelifespan.However,identificationofgenesrelatedtolongevity（referredtoaslongevitygeneshereafter）throughweb-labexperimentssuchasgeneticscreensisatediousandlabor-intensiveactivity.Developinganalgorithmtopredictlongevitygenesshouldfacilitateagingresearch.Inthispaper,wesystematicallyanalyzedpropertiesoflongevitygenesinCaenorhabditiselegansandfoundthat,whencomparedtogenesnotyetknowntobeinvolvedinlongevity,knownlongevitygenesdisplaythefollowingfeatures:

（i）longergenomicsequencesandproteinsequences,（ii）astrongertendencytoco-expresswithothergenesduringatransitionfromdauerstate（anextremelylonglifespan）tonon-dauerstate（anormallifespan）,（iii）significantenrichmentincertainfunctionsandRNAiphenotypes,（iv）highersequenceconservation,and（v）higherinseveralnetworktopologicalfeaturessuchasdegreesinafunctionalinteractionnetwork.Basedonthesefeatures,wedevelopedanalgorithmtopredictlongevitygenesinC.elegansandobtained243novellongevitygeneswithaprecisionrateof0.85.Someofthepredictedgeneshavebeenvalidatedbypublishedarticlesorwetlabexperiments.Thecontributionofeachfeaturetothepredictedresultswasalsoevaluated.

ArticleOutline

1.Background

2.Materialsandmethods

2.1.Datasource

2.2.Networkfeaturecomputation

2.3.Conservationscorecomputation

2.4.Positiveandnegativedatasets

2.5.SupportvectormachineandK-nearestneighbor（KNN）classifiers

2.6.Cross-validation

2.7.Featureselection

2.8.Log-oddsscore

2.9.Lifespanassay

2.10.RNAiexperiments

3.Results

3.1.Longevitygenestendtohavelongersequences

3.2.Longevitygenestendtobemoreconserved

3.3.Longevitygenestendtohavecorrelatedexpressions

3.4.Longevitygenesareenrichedforcertainfunctions

3.5.LongevitygenestendtoshowcertainRNAiPhenotypes

3.6.Networktopologicalfeatures

3.7.Classifierandfeatureevaluation

3.8.Applicationsandvalidation

4.Discussions

5.Conclusions

Contributors

Acknowledgements

AppendixA.Supplementarydata

References

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Researchhighlights

PropertiesofC.eleganslongevitygenesweresystematicallyinvestigated.

Keyfeaturesdistinguishinglongevitygenesfromgenesnotyetknowntobeinvolvedinlongevitywerediscovered.

Anefficientalgorithmforthepredictionoflongevitygeneswasdeveloped.

Someofthepredictedgeneshavebeenvalidatedbywet-labexperiments.

512

Asimulationmodelforlocalizationofpervasiveobjectsusingheterogeneouswirelessnetworks  OriginalResearchArticle

SimulationModellingPracticeandTheory,InPress,AcceptedManuscript,Availableonline27February2011

R.Aversa,B.DiMartino,M.Ficco,S.Venticinque

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AbstractAbstract

Abstract

Positionrepresentsarelevantattributeneededbymanyapplications,whosecontextsarecharacterizedbypervasivenessoftheobjects/thingsintheconsideredscenarios.Inordertoinferpositionsofpervasiveobjects,whichareneitherequippedwithanylocation-sensingtechnologies,norareunabletolocatethemselves,itisneededtosupportthemwithanappropriateinfrastructure,whichallowstodeterminetheirpositioninamannerthatistransparenttoapplications.Inthiswork,weaimatextendingthepositioningserviceusinganagent-basedapproach,inordertodiscoverandlocalizedifferentkindsofobjects,exploitingcheapandembeddedtechnologies.Wedescribethedesignandtheimplementationofalayeredarchitecture,thatsupportsthelocalizationofdevices,andsimplepervasiveandubiquitousobjects.Asimulationtoolhasbeendeveloptoevaluatetheproposedsolutionindifferentapplicationscenariosofevery-daylife.

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513

Intracerebralgammamodulationsrevealinteractionbetweenemotionalprocessingandactionoutcomeevaluationinthehumanorbitofrontalcortex  OriginalResearchArticle

InternationalJournalofPsychophysiology,Volume79,Issue1,January2011,Pages64-72

JulienJung,DimitriBayle,KarimJerbi,JuanR.Vidal,Marie-AnneHénaff,TomasOssandon,OlivierBertrand,FrançoisMauguière,Jean-PhilippeLachaux

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Abstract

Theorbitofrontalcortex（OFC）playsakeyrolenotonlyinprocessingemotionsbutalsoinmonitoringperformanceoutcome.Althoughtheneuroanatomicalsubstratesunderlyingeachofthetwoprocesseshavebeenextensivelyinvestigated,theyhavepredominantlybeenprobedseparatelyandthereforeapreciseknowledgeofthefunctionaloverlapwithinthemultipleOFCsub-portionsinvolvedisstilllacking.Here,weexploretheneuraldynamicsmediatingperformancemonitoringandemotionalprocessingusingdirectintracranial